This inaugural symposium will provide an educational forum for faculty to deliver in-depth reviews of common and rare inborn errors of immunity (IEI). Participants will be able to: Identify hallmark non-infectious comorbidities of humoral immunodeficiency, including pulmonary, gastrointestinal and allergic complications of antibody deficiency; critically appraise diagnostic and management complexities in IEI, including autoimmune disease manifestations, skin diseases.